Explore/agent app/MOOSE-Copilot: A Web-Based Interactive Assistant for Unified Exploratory and Fine-Grained Scientific Hypothesis Discovery
M

Hongran An, Zonglin Yang/MOOSE-Copilot: A Web-Based Interactive Assistant for Unified Exploratory and Fine-Grained Scientific Hypothesis DiscoveryUnknown

Large language models (LLMs) show remarkable potential in scientific hypothesis discovery. However, existing approaches face two critical limitations: they treat divergent exploratory search and convergent fine-grained refinement as isolated tasks, and they operate autonomously with little to no human guidance. We present MOOSE-Copilot, the first unified framework to bridge this abstraction gap through a formalized human-AI interaction (HAII) protocol. Our system empowers scientists to steer the generative process via three explicit signals: initial blueprints, inter-stage routing, and intra-stage feedback. Using an oracle-simulated evaluation in which an LLM provides idealized expert signals, we show that injecting these structured signals significantly outperforms purely autonomous baselines, characterizing the gains achievable under high-quality guidance. Furthermore, we build a web-based interface that turns the framework into a no-code workflow: researchers pose a question, watch the hypothesis search unfold as an interactive tree, and steer it by selecting hypotheses, routing between stages, and injecting feedback-no command-line agents required. This makes end-to-end hypothesis discovery directly accessible to interdisciplinary researchers.

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55 / 100
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55Score
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70C+
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45C
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42C
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58C
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2026-07-262026-07-28
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✓ Best for

  • Research and experimentation
  • Prototype development
  • Learning agentic patterns

◎ Strengths

  • Active community
  • Open source
  • Well-documented API

✕ Not ideal for

  • Untested at scale without validation
  • Teams without AI/ML expertise

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55
Score 55/100
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